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After initial migration, QL responds to an EGL-20/Wnt signal that drives continued posterior migration by activating MAB-5/Hox activity in QL but not QR.
RB1CC1 acts oncogenic in promoting cell survival and migration by activating Wnt signaling, TNF-alpha-induced JNK activity, and mTOR signaling in vitro and in vivo [32], [33].
Accordingly, H2O2 treatment results in an intensive phosphorylation of Axl and enhances cell migration by activating the PI3K/Akt cascade.73 However, the regulatory mechanism underlying ROS-mediated Axl activation remains elusive.
We observed that low-dose IR enhanced endothelial cell migration by activating VEGFR-2.
Conversely, DKK2, a DKK1-homolog, enhances EC migration by activating CDC42 independent of Wnt.
In addition, in the eye Bnl regulates the temporal onset and extent of retinal basal glial cell migration by activating Btl in the glia.
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Rather, it enhances MEC contractility and migration potentially by activating mitogen-activated protein kinase (MAPK) signaling.
Nuclear translocation of NF-κB p65 can promote carcinogenesis by increasing proliferation and migration and by activating the antiapoptotic pathway in cancer cells.
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In conclusion, we show here that Netrin-1-enhanced SCs migration is mediated by activating p38 MAPK and PI3K-Akt signal cascades via receptor UNC5B, which suggests that Netrin-1 could serve as a new therapeutic strategy and has potential application value for PNS regeneration.
For example, miR-106b can promote HCC cell migration and invasion by activating epithelial-mesenchymal transition (EMT) process (Yau et al., 2013).
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