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Thus, stimulation of migration by activated Vav1 involves both EGF receptor-dependent and independent activities induced through the Rho GEF domain of Vav1.
This effect of Cdc42 on EGFR stability has been previously shown to contribute to enhanced cell migration by activated Cdc42 [ 20].
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After initial migration, QL responds to an EGL-20/Wnt signal that drives continued posterior migration by activating MAB-5/Hox activity in QL but not QR.
RB1CC1 acts oncogenic in promoting cell survival and migration by activating Wnt signaling, TNF-alpha-induced JNK activity, and mTOR signaling in vitro and in vivo [32], [33].
We observed that low-dose IR enhanced endothelial cell migration by activating VEGFR-2.
Conversely, DKK2, a DKK1-homolog, enhances EC migration by activating CDC42 independent of Wnt.
Integrins also stimulate cell migration by activating Rho and Rac GTPases (Ren et al, 1999) and by anchoring actin filaments to the membrane.
These data strongly suggest that expression of Vav1Y3F in MCF-10A cells results in secretion of an EGF receptor ligand that stimulates migration by activating the EGF receptor.
Chondroitin sulfate is able to induce FGF-2-mediated controloliferation, cellrol cell adhesion, and stimulate cell spreading and migration by activating focal adhesion of growth factor [ 28, 29].
In addition, in the eye Bnl regulates the temporal onset and extent of retinal basal glial cell migration by activating Btl in the glia.
For example, EGF induces ovarian cancer cell EMT and invasion, migration by activating the ERK1/2 and PI3K/Akt pathways and upregulating Snail, Slug and ZEB1 (Chai et al, 2012).
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