The same microenvironment also supports cell migration, branching and the formation of characteristic acini [16], [17].
Angiogenesis involves various cellular and multi-cellular events such as cell proliferation, survival, differentiation, migration, branching and sprouting.
Fibroblasts have also been shown to facilitate EPC migration, branching, and sprouting in collagen matrices in vitro, potentially via cytokine signaling [ 31].
We conclude that Sdc cell autonomously regulates Slit/Robo2 signalling in tracheal cells to guarantee ordered directional migration and branch fusion.
Indeed, one study found that mouse neurons defective in Elongator exhibit reduced levels of acetylated α-tubulin, causing defects in radial migration and branching of cortical projections neurons [11].
Arsenic exposure altered expression of key genes in pathways involved in lung development, including the β‐catenin pathway, which is required for proper cell migration during branching morphogenesis.
The MET/HGF signaling cascade is involved in regulating a wide array of cellular functions, including cell proliferation, survival and apoptosis, motility and migration, invasion, branching morphogenesis, angiogenesis, and metastasis.
The RecG protein is a DNA helicase and may promote branch migration of a variety of branched DNAs including Holliday junctions [ 19, 20].
Our previous single-molecule fluorescence studies led to a model according to which branch migration is a stepwise process consisting of consecutive migration and folding steps.
Consistent with the increased apparent processivity of branch migration versus DNA unwinding, WRN was reported to promote migration through ∼2700 bp of duplex DNA in an α-structure recombination intermediate that resembles a Holliday junction [50].
