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We also demonstrate that LTD4 mainly internalizes the CysLT1R, supporting our previous findings that LTD4-induced cell survival, cell proliferation, and cell migration are mediated through the CysLT1R.

In addition, it has been shown that the effect of Ang II on vascular SMC migration are mediated via an AT1 receptor dependent signaling pathway involving activation of ERK1/2 [9], and that blocking ERK1/2 activation using the MAPK kinase inhibitor PD98059 or antisense oligodeoxynucleotides can significantly attenuate Ang II-stimulated SMC migration [5].

Lymphatic survival, proliferation and migration are mediated by the vascular endothelial growth factor (VEGF) system [ 12].

These observations suggest that SRC-induced apoptosis and reduced migration are mediated by PTEN, at least in thyroid cancer cells.

Our data suggest that the effects of Nogo-A on migration are mediated by cell surface Nogo-A through a receptor complex that includes NgR and Lingo-1.

In the C. elegans zygote, nucleus-centrosome attachment and pronuclear migration are mediated by the KASH domain protein ZYG-12 and the SUN domain protein SUN-1 (Wood et al. 1980; Malone et al. 2003).

Similar(54)

Owing to the integral role of pS6K in cancer cell migration, it is possible that honokiol-mediated inhibition of migration is mediated through pS6K inhibition.

The way cells explore their surrounding ECM during development and migration is mediated by protrusion of actin-rich structures at the cell front.

These findings support both our hypotheses, first that insect hemocytes can detect and respond to fMLP, and second, that insect hemocyte migration is mediated by eicosanoids.

The way cells explore their surrounding extracellular matrix (ECM) during development and migration is mediated by lamellipodia at their leading edge, acting as an actual motor pulling the cell forward.

In conclusion, we show here that Netrin-1-enhanced SCs migration is mediated by activating p38 MAPK and PI3K-Akt signal cascades via receptor UNC5B, which suggests that Netrin-1 could serve as a new therapeutic strategy and has potential application value for PNS regeneration.

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