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Their development, migration and synaptogenesis is then halted until the 4th postnatal month when a second generation of cells begins to develop in a process that continues until the 4th year of life.
Adhesion molecules, such as NCAM, L1, or TAG1, have pivotal roles in axonal growth and fasciculation, neural cell migration and synaptogenesis [6], [7], [8], [9], [10].
Rakic (1988) described three broad phases of brain development in rhesus monkeys: generation of neurons, neuronal migration, and synaptogenesis.
This time corresponds to the postnatal growth surge in rodents, which includes apoptosis, migration, and synaptogenesis of the brain tissue.
How are the development of the cerebellum (e.g., granule cell migration and synaptogenesis) and the formation of cerebellar cortical connections influenced by play?
Play during early childhood coincides with cerebellar granule cell migration and synaptogenesis, and since the cerebellum has a known role in predictive timing, play may be the key to the development of this ability.
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Protocadherins (PCHD) are cell adhesion proteins with an important role in neuronal migration, differentiation and synaptogenesis.
Previous studies have revealed a critical role for 5-HT in numerous physiological processes, including cell division, neuronal migration, differentiation and synaptogenesis.
In animals, hypothyroidism affects neuronal proliferation, migration, myelination, and synaptogenesis (Ibarrola and Rodriguez-Pena 1997; Nicholson and Altman 1972; Rami and Rabie 1990).
Experimental evidence showed that both BDNF and SYN1 are involved in critical developmental processes of the nervous system, including proliferation, migration, differentiation, and synaptogenesis (Bernd 2008; Fornasiero et al. 2010).
Spontaneous neuronal activity, a feature of the developing CNS, influences fundamental processes of brain development, such as cell migration, neuronal maturation, and synaptogenesis (Moody and Bosma, 2005).
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