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These CAMs transduce signals from outside to inside, but they also can transduce signals in the opposite direction because of their functions in cell migration and synaptic plasticity.
Finally, we assessed the expression of BDNF, a neurotrophic factor provided with multiple effects on brain plasticity that regulates neuronal survival, cell migration and synaptic function [20], [27].
In addition to regulating neuronal migration and synaptic plasticity, semaphorins have also been found to be involved in the development of other organ systems [49].
tPA appears to be the primary PA expressed in the intact CNS and is involved in neuronal migration and synaptic plasticity (Seeds et al., 1997, 1999, 2003).
Other, more specific terms are also visualized such as regulation of apoptotic process, I-kappaB kinase/NF-kappaB cascade, glial cell migration, and synaptic transmission and synapse organization.
The CMIP protein forms part of the cellular scaffold linking the plasma membrane to the cytoskeleton [ 71], and cytoskeletal remodeling represents a critical step in neuronal migration and synaptic formation processes.
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The differentially expressed genes are involved in a variety of processes, including nerve cell differentiation, migration, myelination and synaptic transmission.
These chemokines are involved in chemoattraction of immune cells to sites of tissue damage but have widespread non-immunological effects in the central nervous system, including regulation of neural cell proliferation, migration, survival and synaptic transmission [ 62, 63].
After decades of intense investigation, NTs, which include nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT3) and -4/5 (NT4/5), are now known to govern almost every aspect of neuronal physiology, as they modulate neuronal survival, migration, differentiation and synaptic plasticity.
DISC1 is known to be critical for neural precursor proliferation and differentiation, neuronal migration and integration and synaptic signalling within the developing and adult brain (46).
Specifically, REST is a master developmental regulator that controls a large suite of genes that encode proteins critical for neuronal maturation, such as cellular migration, axonal pathfinding, and synaptic transmission (Johnson et al., 2007, 2008; Otto et al., 2007).
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