ESR1 inhibits cell migration and the repression of ESR1 expression enhances cell migration and accelerates tumour formation and metastasis.
BMI1 controls MB cell migration and invasion through repression of the BMP pathway, raising the possibility that BMI1 could be used as a biomarker to identify groups of patients who may benefit from a treatment with BMP agonists.
Overexpression of miR-21 reduced EC proliferation, migration, and tubulogenesis through repression of Rho-B, whereas miR-21 inhibition resulted in opposite effects, indicating the antiangiogenic function of miR-21 [ 68].
Endostatin has various antitumor functions through regulating a variety of receptors, including inhibition of angiogenesis and repression of migration and invasion of tumor cells [ 41, 42].
miR-203 negatively regulated proliferation and migration through the repression of PKC- α, and miR-203 was also able to modulate cell apoptosis.
Functionally, NORAD elicits potent inhibitory effects on migration and invasion of multiple lung and breast cancer cell lines, and repression of NORAD expression participates in the migration- and invasion-stimulatory effects of the YAP pathway.
Our results identify miR-21 as a new angiogenesis inhibitor and suggest that inhibition of cell migration and tubulogenesis is mediated through repression of RhoB.
Taken together, the restoration of miR-591 reverses the sensitization of drug-resistant ovarian cancers to PTX, and reduces cancer cell migration and proliferation, probably by the repression of its target genes, ZEB1.
These miRNAs mediate metastasis through increased invasion and migration by targeted repression of tricho-rhino-phalangeal syndrome type 1 protein (TRPS1), which in turn increases the abundance of the EMT-promoting protein zinc finger E-box-binding homeobox 2 (ZEB2).
Experimental evidence suggests that Wnt signaling promotes and regulates stem cell division, differentiation, and possible cell migrations while intestinal BMP signaling inhibits stem cell self-renewal and repression in crypt formation.
