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Every tissue has an ECM with unique composition and topology that governs the process of determination, differentiation, proliferation, migration and regeneration of cells.
To overcome this limitation, we genetically engineered male rat MSCs overexpressing CXCR4 in order to maximize the effect of stromal cell-derived factor-1α (SDF-1α) for cell migration and regeneration.
In addition to the overall rigidity response being altered in malignantly transformed cells in vitro [25], similar behavior was described in vivo [26], [27] further emphasizing the relevance of proper mechanosignaling to complex processes such as differentiation, development, migration, and regeneration.
While, ANP and its downstream molecules could induce endothelial cell proliferation, migration and regeneration after vascular injury [ 15, 16].
More recent experimental studies showed that after skin wounding, K6 and K16 are rapidly induced within 6 h in human keratinocytes at the wound edge, before migration and regeneration begins (Paladini et al. 1996).
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To date, tissue engineering approaches focus on either cells delivery to the tissue of interest, or scaffold-based delivery of signaling molecules to stimulate cell migration, differentiation, and regeneration [ 1– 5].
In this study, we explored the effect of cytokine mediated 'biasing' of macrophage phenotypes on Schwann cell (SC) migration and axonal regeneration in vitro and in vivo.
The intraluminal fibres were shown to be successfully incorporated into the host regenerative process, acting as a platform for Schwann cell migration and axonal regeneration.
Endogenous electric signals, such as spatial gradients of resting potential among non-excitable cells in vivo, have also been shown to be important in cell proliferation, differentiation, migration, and tissue regeneration, and may therefore have as-yet unexplored therapeutic potential for regulating wound healing in bone tissue.
As a late-acting proinflammatory cytokine, HMGB1 mediates many crucial pathological processes such as inflammation, cell migration, and tissue regeneration [ 42].
Polyamines produced from arginine have previously been shown to be essential both in early mucosal restitution by cell migration and in regeneration by proliferation [ 56].
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migration and recovery
migration and renewal
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migration and survival
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migration and differentiation
migration and climate
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migration and relocation
migration and group
migration and youth
migration and urbanisation
migration and asylum
migration and diversity
migration and openness
migration and loss
migration and mobility
migration and automation
migration and population
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