Cytokines, such as IL-1, IL-6, and TNF- α, are also relevant mediators for leukocyte migration and participate in several inflammatory conditions.
Furthermore, in cutaneous malignancies, mast cells have been shown to be involved in tumourigenesis by suppressing the immune system, facilitating endothelial cell migration and participating in the degradation of the ECM [ 44].
From these studies, we found that both of these proteins were involved in cell adhesion and migration and participated in the interaction between tumor cells and stromal cells, although FXYD-3 was mainly expressed in the tumor cells, while PINCH was mainly expressed in the stromal cells.
In many circumstances, EMT leads to increased translocation (migration) ability and participates in cancer metastasis [ 28– 30].
The intracellular adaptor TRIB3, a human homolog of Drosophila tribbles, has been found to interact with a variety of signalling molecules to regulate diverse cellular functions including cell proliferation, migration and morphogenesis by participating in protein complex assembly.
An example is the CD44 gene, encodeing a cell-surface glycoprotein, involved in cell-cell interactions, cell adhesion and migration, which participates in a wide variety of cellular functions including lymphocyte activation, hematopoiesis, and tumor metastasis [40].
GAO and P-PK carried out the in vivo studies, the migration and zymography studies, FL participated to the in vivo studies, CC and JA participated to the histology studies, SB participated to the in vivo studies.
Ezrin plays a positive role in maintaining cell shape and polarity and participates in cell migration, signaling, growth regulation, and differentiation [ 10].
We analysed the effect of biglycan on vinculin, which is a key regulator of focal adhesions and participates in cell migration.
Adhesion of PMNs to ECM proteins has been shown to be important for their migration, and is thought to participate in PMN recruitment to sites of inflammation.
