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Jeon, H. et al. Directing cell migration and organization via nanocrater-patterned cell-repellent interfaces.
DOCK8 was shown to be involved in immune synapse formation, lymphocyte migration and organization of cell shape19.
Under pro-angiogenic conditions in vitro, the ECM-like nano-network provided the structural and organizational stability for ECs' migration and organization into capillary-like structures.
We show that the physical incorporation of Tβ4 in this bioactive matrix creates a three-dimensional (3D) environment conducive for human umbilical vein endothelial cell (HUVEC) adhesion, survival, migration and organization.
We can now achieve spatial control over the path and direction of migration in addition to temporal control of the onset of migration, enabling studies that better recapitulate coordinated multicellular migration and organization in vitro.
Endothelial cell proliferation, migration and organization into tubes are key mechanisms of angiogenesis.
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Mutations in either SUN or KASH proteins that result in defective LINC complex assembly lead to severe failures in nuclear migration, anchorage and organization [24] [29].
Carmi et al. have demonstrated that macrophage-derived IL-1 activates infiltrating myeloid cells to produce VEGF, thus inducing endothelial cell migration, proliferation and organization into blood vessel-like structures and promoting tumor angiogenesis [57].
In their Matrigel plug system, Carmi and colleagues have shown that neutralization of IL-1 completely abrogated cell infiltration and angiogenesis and significantly reduced VEGF levels, thus inducing endothelial cell migration, proliferation and organization into blood vessel-like structures and promoting tumor angiogenesis [57].
Using the aortic ring sprouting assay, IL-1 does not directly activate endothelial cell migration, proliferation, and organization into blood vessel-like structures, but rather activates infiltrating cells to produce VEGF.
In this context, the adoption of elastin-based materials has raised a strong attention by mimicking many features of the extracellular matrix with a potential to promote the migration, growth, and organization of cells during regeneration processes [ 10– 10].
More suggestions(15)
migration and survival
migration and repair
migration and diversity
migration and filament
migration and invasion
migration and proliferation
migration and differentiation
migration and wear
migration and accumulation
migration and urbanisation
migration and return
migration and development
migration and replication
migration and death
migration and mobility
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