In addition, LKB1 itself has roles in regulating cellular polarity and structure, such as promoting axon initiation during neuronal polarization in cultured hippocampal neurons (Shelly et al. 2007) and regulating neuronal migration and neuronal differentiation in the developing neocortex (Asada et al. 2007).
Asada, N., Sanada, K. & Fukada, Y. LKB1 regulates neuronal migration and neuronal differentiation in the developing neocortex through centrosomal positioning.
In contrast, PuraMatrix was the most optimal hydrogel for hNSCs, since it showed low toxicity when gelated (0.25%) and retained several crucial properties of hNSCs, including migration and neuronal differentiation.
Furthermore, AQP4 might be involved in the proliferation, survival, migration and neuronal differentiation of adult neural stem cells (ANSCs) [20].
The neural cell adhesion molecule L1 is a member of the immunoglobulin superfamily [9], [10], [11], [12] that has been shown to promote neurite outgrowth, neuronal migration, and neuronal survival [9], [10], [12], [13], [14], [15], [16].
In this context, it is intriguing that the mammalian Cas family NEDD9 gene is abundant during neuronal development, has been proposed as a candidate locus for oral cleft defects in humans based on its chromosomal location near the OFC-1 locus [65], and has recently been implicated in control of neural migration and neuronal cell fate [66], [67].
In contrast, migration, survival, and neuronal fate choice seem to be less dramatically affected, as they seem only to be delayed in the aged DG.
Doublecortin is a microtubule-associated protein playing essential roles in cortical neuronal migration and growth of neuronal processes [36] [38].
VEGF and kallikrein share a series of effects such as enhancing the survival and migration of neuronal and glial cells, promoting angiogenesis, protecting against ischemia, apoptosis, and glutamate-induced neurotoxicity [ 41].
For example, acute tau knockdown during embryonic development delayed neuronal migration and cell-autonomously reduced neuronal complexity and connectivity, 86 problems that appear to be restricted to early developmental stages.
PSA is involved in dynamic processes like cell migration, neurite outgrowth and neuronal plasticity.
