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Non-canonical signaling also increases the migration and metastatic potential of melanoma cells [14], [15].
Moreover, increased RANKL expression is related to migration and metastatic propensity of prostate tumor cells and renal cell carcinomas [21], [22].
Results show that PTEN may act as a barrier to cancer development by controlling cellular polarity, establishment of cell-cell junctions, paracellular permeability, migration and metastatic potential of human colorectal cancer cells.
Anoikis is associated with cellular migration and metastatic potential.
Therefore, we presume that Sp17 could promote the migration and metastatic activity of cancer cells.
The activation of TGFβ signaling promotes single tumor cell migration and metastatic spread into blood vessels and lymph nodes.
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Blockade of autocrine TGFβ signaling induced apoptosis and inhibited cell migration, invasion and metastatic potential.
Signaling via both the FGFR-1 and PDGFR has been associated with increased migration, invasion and metastatic potential [ 29- 33].
There is accumulating evidence that EMT confers migration, invasion, and metastatic capacity, and multidrug resistance to tumor cells [ 33, 34].
Depletion of ARMS inhibited migration, invasion, and metastatic potential of melanoma cells in vitro and in vivo.
We previously reported that knockdown of CLDN4 increased the migration, invasion and metastatic potential of 2008 cells [ 18].
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