Rac plays important roles in breast cancer cell migration and invasiveness and is upregulated in invasive human breast cancer [ 7- 9, 11- 13].
Recent studies have confirmed that PTHrP massively contributes to malignant behaviour of oral cancers-cell proliferation, migration and invasiveness.
High rate of proliferation, active migration, and invasiveness into non-neoplastic tissues are specific properties of neoplastic transformation.
Consistently, fibroblast expression of Cav1, through p190RhoGAP regulation, favors directional migration and invasiveness of carcinoma cells in vitro.
An understanding of how integrins regulate cell migration and invasiveness through the dynamic regulation of adhesions is fundamental to both physiological and pathological situations.
These findings support a role for AR in cell migration and invasiveness.
These results support the role of FAK in non-genomic signaling of steroids leading to cell migration and invasiveness.
Given the major role of VEGF-A in regulating migration and invasiveness, we were first interested in whether VEGF-A could modulate FLJ10540 protein expression.
Using multiple cell line models of GBM, it was determined that expression of E-cadherin correlated with growth, migration, and invasiveness.
Both Par-6 and PKC-ζ have been identified as EMT-associated biomarkers [42] and found to enhance proliferation, migration and invasiveness in cell cultures [43], [44].
By ectopic expression of DLC1 in HCC cell line, we previously showed that DLC1 significantly repressed HCC cell migration and invasiveness [4].
