The migration and invasive capabilities as well as the proliferation of HOS cells were suppressed by the administration of small interfering RNA (siRNA).
In figure 4C, CL1-0 cexhibitedbited more migration and invasive abilities in the presence of VEGF-A alone than VEGF-A combined with SU5416 or vehicle alone, suggesting that the addition of VEGF-A significantly increased the migration and invasion of CL1-0 cells, which was paralleled by an increase in FLJ10540 levels.
Globally, our results show that exogeneous CXCR4 overexpression in IGR-N91 does not further increase their in vitro growth, migration and invasive properties, indicating that a subtle threshold of endogenous CXCR4 level necessary and sufficient for mediating growth, survival and migration is reached in these cells.
We next monitored cell migration and invasive behaviour in vitro.
This is in line with our in vitro analysis of cell migration and invasive potential.
Genes involved in proliferation, cell migration, and invasive activity were repressed in RT-inhibited cells.
These results suggested that miR-375 contributes to suppress both LSCC cell migration and invasive capacity in vitro.
Over-expression of WNT7A in an ovarian cancer cell line led to increased migration and invasive capacity.
One of the most important biological functions contributing to S100A4-induced metastasis is increased cell migration and invasive capacity.
Stable over-expression of hSef resulted in reduced in vitro cancer cell proliferation, migration and invasive potential.
Migration and invasive properties were evaluated in a 24 well transwell chamber assay, 8 μM pore size (Costar, Cambridge, MA).
