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Sodium arsenite exposure has been shown to cause alterations in cell adhesion to the cell culture substrate at concentrations well below the concentration used here, as well as alterations in cell migration and focal adhesion localization [28].
11, 13, 12, 14, 15 Knockdown of Capn4 results in decreased migration and focal adhesion of fibroblasts cells.
Simultaneously, our results demonstrate that magnolin inhibited the activity of MMP-2 and MMP-9, which are critical enzymes involved in cell migration and focal adhesion.
Nox4 mRNA and protein, ROS production, cell migration, and focal adhesion kinase (FAK) activation were examined in three different cell models based on their p53 mutational status.
Migration and focal matrix degradation, two components of cellular invasion, were assessed in FAK-inhibited rheumatoid synovial fibroblasts by transwell assay and microscopic examination of fluorescent gelatin degradation, respectively.
Impaired neuronal migration and focal areas of enhanced neuronal apoptosis are the typical pathological alterations in the medial neocortex of Pex11β −/− mice and other ZS mouse models (Baes et al., 1997; Baes et al., 2002; Faust and Hatten, 1997; Li et al., 2002a; Li et al., 2002b; Maxwell et al., 2003).
Similar(54)
The effects of cAMP on migration, ruffling and focal adhesions are mediated by PKA whilst EPAC potentiates migration.
Moreover, it also promoted endothelial (progenitor) cell migration, adhesion and focal contact formation, concomitantly with the decreased synthesis of NO and the activity of superoxide dismutase (SOD) [ 10, 18, 19].
Recently, it has been reported that overexpression of profilin-1 up-regulated the expression of ICAM-1, increased endothelial cell permeability, induced endothelial cell apoptosis and promoted endothelial cell migration, adhesion and focal contact formation [ 7, 9] and silencing profilin-1 gene expression provided significant protection on endothelial cells [ 28].
128 The authors were able to demonstrate that the effect on metastasis was linked to the phosphorylation of two tyrosine-kinase proteins involved in migration and adhesion: focal adhesion kinase (FAK) and Src.
A reduction in SLK levels or activity negatively affects cell migration and microtubule-dependent focal adhesion turnover, suggesting that SLK is required for cell motility.
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