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These findings provide evidence that the PSHU-RGD/PCL conduit offers a microenvironment conducive to hNSC survival, migration, and extension.
This study demonstrates: (1) renewal of intestinal epithelial lining in the graft biopsies during initial hours after transplantation is more likely caused by migration and extension of remaining epithelial cells than by their increased mitotic division.
We have characterized two Pak pathways that are required for proper migration and extension of DTCs during gonadal development.
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The migration and rank extension on the hash rules are defined to achieve load balancing and capacity expansion.
hNSCs were cultured on the nerve guidance conduits to determine if cell migration and neurite extension are enhanced.
In this study, a biochemically and topographically controlled synthetic nerve conduit was developed with emphasis on promoting neuronal cell survival, migration, and guided extension.
Since hNSC survival, migration, and guided extension with the PCL conduit was not observed, no further examination by confocal microscopy was performed.
Furthermore, the design concept of this conduit could provide a platform for improved nerve regeneration with enhanced cell survival, migration, and guided extension.
In particular, photoreceptor degeneration stimulates deposition of the inhibitory ECM proteins neurocan and CD44 at the outer limits of the dystrophic retina, where they act as a barrier against cellular migration and axonal extension.
Quite contrary, the function of DCX is generally seen in maturation processes responding to extrinsic stimuli [23], most notably cell migration and neurite extension, all of which we find in the DCX phase of adult neurogenesis in rodents.
6 PES1 mutant overexpression disrupted oligodendrocyte development, oligodendrocyte migration, and axon extension.
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