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Reported functions of DISC1 include regulation of intracellular signalling pathways, neuronal migration and dendritic development.
Morgan-Smith, M., Wu, Y., Zhu, X., Pringle, J. & Snider, W. D. GSK-3 signaling in developing cortical neurons is essential for radial migration and dendritic orientation.
Since Dcx and neurabin II colocalized in the developing and adult brain, a neurabin II DCX heterodimer may be involved in neuronal migration and dendritic spine formation.
Sun1 and Sun2 have a dosage-dependent but non-redundant effect on the migration and dendritic morphogenesis of Purkinje cells.
In this work, we have documented a cell autonomous requirement for GSK-3 signaling in migration and dendritic orientation of cortical excitatory neurons.
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In addition, ornithine decarboxylase activity was temporally associated with regions in which post-mitotic cells were undergoing migration, axonogenesis and dendritic arborization, as shown by the patterns obtained in deeper layers.
The behavioral consequences of migration failure and dendritic arbor abnormalities could not be assessed due to early death of the Gsk3-mutant animals.
The existing techniques allow the assessment of specific neuronal migration, axonal and dendritic outgrowths, pruning, synaptogenesis, development of neuronal circuits, and their ultimate function behavior (Tables 2 and 3).
Recent studies have also shown that neurotoxic forms of Aβ can perturb multiple aspects of neuronal motility, including neuronal migration, outgrowth and dendritic remodeling (Shrestha et al., 2006; Evans et al., 2008; Crews and Masliah, 2010).
Developmental exposure to either Aroclor 1254 or decaBDE disrupted a number of cell-signaling pathways in the hippocampus that are associated with cell proliferation, migration, axonal and dendritic extension, and synaptogenesis (Pruitt et al. 1999; Royland and Kodavanti 2008; Viberg et al. 2008).
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