In summary, our results suggest that HDL and SR-BI have pro-oncogenic activity and can induce migration and activate signal-transduction pathways responsible for cellular proliferation and tumor formation in two breast cancer cell lines.
Exposure of endothelial cells to dR and TP stimulated both the migration and invasion, and activated the focal adhesion kinase (FAK) and p70/S6k (Hotchkiss et al, 2003; Seeliger et al, 2004).
4, 14 Here, we show JAML expression by primary cultures of human BBB‐ECs and demonstrate that JAML blockade compromises the migration of monocytes and activated CD8 T cells.
Functionally, MMP-14 enhances cell migration and activates MMP-2 which in turn promotes invasion and metastasis [ 6].
We found that HDL3 stimulates migration and activates signaling pathways such as MAPK and PI3K in two breast cancer cell lines.
sVCAM-1 is a cell-surface molecule that regulates leukocyte migration and is activated by proinflammatory factors such as cytokines and interleukins [ 49].
In D. melanogaster, Toll receptor protein accumulates during the embryonic syncytial stage prior to nuclear migration, and is activated ventrally as the result of a serine/protease cascade (references in Additional file 1).
The arrival of moist southwesterly wind in the lower troposphere is associated with the large-scale seasonal migration of low-level convergence and activated the Asian summer monsoon in the Philippines (Wang 2006).
Taken together these results show that Notch activity on BM-PC is necessary (via integrin modulation) for their ability to recognize and adhere to exposed ECM and activated endothelial migration.
