It was noted by researchers that although NT-3 had positive effects on SC migration, activation of SC-TrkC receptors inhibited myelination [ 146, 149, 150].
In fact, S100a8/a9 is involved in several steps of the inflammatory response including leukocyte differentiation and chemoattraction, transendothelial migration, activation of immune and epithelial cells, and the induction of pro-inflammatory mediators [ 7].
Chemokines are classified into C, CC, CXC, and CX3C subclasses based on the conserved cysteine motifs [ 11], and are involved in cellular migration, activation of adhesion molecules, cellular proliferation, cytokine production and regulation of apoptosis [ 12, 13].
Recent evidence suggests that these proteins can also regulate non-leukocyte cell functions such as angiogenesis/angiostasis, cell migration, activation of apoptotic cell death, and proliferation (Wang et al, 1998).
Interestingly, and importantly with regard to the functional role of DDR2 in fibroblast migration, activation of DDR2 and the DDR2-associated kinases JAK2, and ERK1/2 appear to be involved in fibroblast migration through collagen IV even though DDR2 is not able to recognize collagen IV.
