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Stimulated monocytes activate pro-survival pathways, migrate to tissues and differentiate into macrophages.
Large phagocytes developed from circulating monocytes that migrate to tissues to eliminate cellular debris and particulate antigens.
Substantial work needs to be done in understanding what causes different types of carriers to migrate to tissues differentially.
In these cells, the virus might be maintained and could subsequently migrate to tissues and/or organs in infected neonatal monkeys.
CXCR4 is upregulated in metastatic breast cancer cell lines and lymph node metastasis [ 62], and cells expressing CXCR4 predominantly migrate to tissues that express the ligand CXCL12 [ 62].
Considering that the peritoneal cavity serves as an alternative site for immunotherapeutic procedures, the present study investigates the possibility that peritoneal phagocytes migrate to tissues infected by fungi.
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Circulating monocytes migrate to tissue and differentiate into macrophages [ 9].
Although pDCs are probably migrating to tissues and producing IFN- α there, we did not observe any difference in the percentage of circulating pDCs between SLE patients and healthy controls.
After migrating to tissues (e.g., lung), monocytes can differentiate into macrophages and dendritic cells which are major phagocytes that engulf M. tb and induce adaptive immunity [ 34, 35].
Whereas CCR7- TEM remain in the peripheral tissue, CCR7+ TEM migrate to peripheral tissues and subsequently exit the tissue to enter draining lymph nodes in different animal models [ 31, 32].
In addition to the above results, BM MSC have been identified as progenitors of mesenchymal tissues because they can migrate to injured tissues to repair them.
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