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Interneurons originating from the ganglionic eminence migrate tangentially into the developing cerebral wall as they navigate to their distinct positions in the cerebral cortex.
Interneurons, arising from the ganglionic eminence (GE), migrate tangentially into the developing cerebral wall along the marginal zone as well as through the intermediate zone in a presumed radial glial independent manner, using corticofugal fibers as substrates [5] [15], although a functional relationship between radial glia and migrating interneurons has also been suggested [16].
Upon arriving into the core of the OB, DCX+ neuroblasts migrate tangentially into the granule cell layer (GCL) where they differentiate into NeuN+ neurons.
In contrast to glutamatergic cortical neurons that originate from progenitors located in the pallium, cortical interneurons are generated in the subpallium and migrate tangentially into the cerebral cortex.
It appears that in the rodent 95% of inhibitory interneurons are born in the medial (MGE) and caudal (CGE) ganglionic eminences of the subpallium and migrate tangentially into the cortex (Márin and Rubenstein 2001).
Throughout this sequence, a small complement of non-pyramidal neurons (<10% of total) generated at the margins of the dorsal pallium migrate tangentially into the developing neocortex (Del Rio et al., 1997; Meyer and Wahle, 1999; Hevner and Zecevic, 2006).
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At all phases of migration, cells were seen to migrate tangentially in one direction, only to reverse direction at a later time.
Therefore, it is possible to speculate that SPIG1-positive and -negative cells migrate tangentially in the GCL to yield a minimal distance between the homotypic cells.
In the adult brain, neuroblasts generated from the subventricular zone (SVZ) migrate tangentially in chains up to the core of the OB, where single cells detach from chains and start to migrate radially [1], [4].
From their place of birth they then migrate tangentially thereby covering the entire cortical mantle into the cortical pre-plate.
Some dACs were seen to migrate tangentially at this stage, in a manner reminiscent of tangential migration of HCs at the OPL (supplementary material Fig. S4B).
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