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Taken together, these data show that a relatively large number of genes is differentially expressed between CRI-G1-RR and CRI-G1-RS cells and that these genes are involved in a number of distinct biological pathways; gene expression changes that might underlie differential vulnerability to mitochondrial and oxidative stress are discussed in more detail in the next section.
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Do unique requirements for mitochondrial dynamics underlie differential neuronal vulnerability?
We next hypothesized that the differential response to NB-598 might underlie the dramatically different cellular responses observed in the panel of SCLC cell lines.
It has been described that differential expression of apoptosis-related genes might underlie tumor-specific differences in susceptibility to an efferent arm of the immune response, i.e., immunologic cytotoxicity [ 37].
We are currently exploring how differential phosphorylation and acetylation of mitochondrial proteins might underlie the metabolic suppression seen in these hibernators.
Another mechanism that might underlie differences in the transcriptional response to TCDD between mouse and rat is the differential activity of one or more regulatory genes.
The observed differential NTAs between core and accessory enzymes and within each of the two classes might underlie the stoichiometry of the protein products.
This study does not provide insight into the mechanisms that might underlie these results, although we have previously ruled out self-report bias between runners and non-runners by differential validation against spousal values [ 21].
Longitudinal data that focuses on differential changes between appetitive aggression and PTSD would help to better understand the dynamic processes that might underlie the processing of violence and mental health symptoms.
Impaired empathic abilities might underlie this association.
What biological mechanism might underlie the observed effects?
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com