However, deciphering the Ahr-specific transcriptional response is not a trivial task, considering that Ahr activation might trigger the activation of other TFs or the generation of toxic metabolites which will add side effects to the observed differential gene expression.
Activation of the latter receptors depolarizes NG2 cells, which might trigger the activation of Cavs.
Alternatively, Tir-bound Nck might trigger local activation of GC-GAPs [ 130], which were reported to specifically inactivate Rac-1 and Cdc42.
Alternatively, Tir-bound Nck might trigger local activation of GC-GAPs (Zhao et al., 2003), which were reported to specifically inactivate Rac-1 and Cdc42.
Hence, it could be speculated that IL-18 in combination with a hyperglycemic proinflammatory milieu might trigger Th1 activation and IFN-γ production [ 63], both in adipose tissue and in the atherosclerotic plaque.
The ability of growth factors to trigger activation of Rho and Rac GTPases along with actomyosin cytoskeletal reorganization and formation of focal adhesions might well play a crucial role in lens epithelial cell proliferation, migration, elongation and survival.
RTK constitutive signaling might trigger the constitutive activation of the survival pathway through MEK or AKT activation, therefore accounting for the combined effect observed in our cell line panel both in vivo and in vitro.
MMP activation in HAP might be necessary for bacterial clearance, but unresolved infection might trigger ongoing MMP activation and tissue destruction[ 26, 27].
Adipocytes and residing macrophages can also locally produce cytokines, which might trigger M2 type activation.
This suggests that different pathogens might trigger distinct NK-cell activation pathways, or, alternatively, that the production or function of the NK-cell-activating cytokines is interdependent so that the respective gene-deficient mice exhibit a similar defect of NK-cell activation.
