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An effective treatment against L1CAM-positive tumour cells in the peritoneal cavity might therefore decrease the amount of free tumour cells (spheroids) potentially reducing the burden of occurring ascites.
Calcipotriol might therefore decrease HBD2 expression in keratinocytes by two mechanisms: by directly blocking the induction of HBD2 through inhibition of Nf-κB and by lowering the tissue levels of IL-17A.
An increase in p110α levels, such as through PIK3CA gene amplification, might therefore decrease p85α homodimerization leading to PTEN destabilization.
A younger age at menopause indicates less exposure to ovulatory cycles and might therefore decrease ovarian cancer risk according to the incessant ovulation hypothesis.
Indeed, inflammation has been known to promote de novo methylation, and ASA might therefore decrease DNA methylation levels at inflammatory-sensitive loci through its anti-inflammatory properties [ 30].
As increasing numbers of records are coded each year, coders may have less time to code each one and might therefore decrease the number of codes per record.
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Hence, lean children might harbor 'obesity alleles' and therefore decrease the power of the association study.
Thus, higher GDF15 levels in A2780cis tumors might decelerate tumor growth and therefore decrease the accessibility to replicating DNA for platinum compounds.
Fever reduction might, therefore, have decreased synthesis of protein that would occur at the expense of muscle protein catabolism and loss in body weight [ 48].
On the other hand, MPCR which could decrease the use of antibiotics [43] might decrease the rate of inappropriate antibiotic therapy and therefore decrease the antimicrobial resistance development [25].
On the other hand, MPCR which could decrease the use of antibiotics [ 43] might decrease the rate of inappropriate antibiotic therapy and therefore decrease the antimicrobial resistance development [ 25].
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