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The non-essential nature of PCFS4 for plant viability and specific developmental defects of pcfs4 mutants support a hypothesis that PCFS4 might specifically target on a subset of genes.
Thus, we speculated that the Mieap-regulated lysosomes might specifically target and degrade the oxidized proteins in mitochondria.
These observed features provided a clue that CrSPI-1-D1 might specifically target thrombin after modifications of a few residues in the RSL, and this prompted us to change the specificity of CrSPI-1-D1 targetgethrombinin.
Hence a missense mutation in the CHD4 ATPase domain might specifically target the tumour-suppressing DNA-repair activity of CHD4 without compromising the p53-antagonizing functions of NuRD.
Therefore, we propose that class R INH-ODNs might specifically target autoreactive B cells and thereby also inhibit pDC-mediated IFN-α production.
This interaction was associated with enhanced degradation of LATS1 and suggest that ITCH might specifically target the activated form of LATS1.
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I Call Myself a Feminist might be specifically targeted at younger women but readers of any age stand to learn a whole lot from this anthology.
In order to compare LytM and LytM H291A production in vivo and to rule out the possibility that the inactive LytM H291A protein might be specifically targeted by proteases, we performed Western blot experiments with polyclonal LytM antibodies.
This suggests that the recent coselection in EAS might have specifically targeted the nervous system.
Hence, differently composed LRRC8 channels can also differ in their pharmacology, and cisplatin-conducting VRACs might be specifically targeted without abolishing ICl,vol and cell volume regulation.
Previous evidences have suggested that Klf4, which is a zinc finger transcription factor, can function as both a tumor-suppressor gene and an oncogene and might be specifically targeted by certain HDACs.
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Justyna Jupowicz-Kozak
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