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The different abilities of Erlotinib and Gefitinib should be further established, as they might require dose adjustments or different treatment durations.
While these practical measures may be used to manage grade 1 symptoms, effective management of grade 2 and grade 3 symptoms might require dose modifications or interruptions.
†Includes myopathy with statin treatment, or clinically relevant altered plasma concentration (for example, of digoxin, lithium, ciclosporin, or theophylline), which might require dose alteration or closer monitoring.
Significant renal impairment was defined as the combination of these two (i.e. those with eGFR less than or equal to 60 mls/min/1.73 m) as this population might require dose alteration to antiretroviral treatments.
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Since neonates and infants have immature coagulation system than adults [3], and the plasma clearance of rFVIIa is significantly higher in children than in adults (67 ml/kg/h in children, 36.6 ml/kg/h in adults) [3], children might require larger dose of rFVIIa than adults to achieve appropriate hemostasis.
25 In addition to careful blood-pressure monitoring and attentive review of the antihypertensive regimen, effective management of treatment-induced hypertension might require regorafenib dose modifications.
However, one cannot completely exclude that some modifications produced by the enzymatic deficiency persist even after enzyme recovery because some alterations might require higher dose and/or longer incubation time to be reversed or could be irreversible.
These patients might have been prescribed medications that either did not require dose adjustment or nephrotoxic medications might have been avoided or switched to safer drugs.
A greater thrombotic burden in acute ST-segment elevation myocardial infarction (STEMI) might require higher doses and/or intracoronary delivery of glycoprotein IIb/IIIa inhibitors to achieve optimal PAI.
Live, attenuated AI vaccines might require fewer doses and might provide broader immune responses than inactivated or subunit vaccines.
13 14 15 Moreover, optimal therapeutic benefits of paracetamol might require regular doses of up to 4000 mg/day.
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