In a different cell type or when using cancer cell lines that have different transcriptional programs with specific oncogenes prominently expressed, miR-125b overexpression might repress the expression of these oncogenes and thereby serve as a tumor suppressor.
In PB, RBP-J deficient EPC have up-regulated CXCR4, implying that Notch signaling might repress CXCR4 expression and EPC recruitment to injured tissues, since literature has indicated that the CXCR4 expression is closely related to the EPC recruitment into injured tissues, which produce SDF-1α [21], [21].
The rapid loss of the Esg-expressing cell population upon Pdm1 overexpression suggests that Pdm1 might repress Esg expression, perhaps directly (Fig 6).
This suggested that wound-induced Dpp might repress AMP expression via Mad.
Thus, TCP23as induction by nitrate might repress TCP23 expression, controlling meristematic activity of the primary root.
Similarly, it seems plausible that AS2 and BOB1 might repress the expression of class 1 KNOX genes via two independent pathways.
The latest observation suggests that the β-ZIP identified here might repress the expression of a floral-promoting factor in both Nicotiana species.
The authors made the interesting hypothesis that GATA2 might repress the expression of the erythroid markers in maturing megakaryocytic cells since its activation inhibits erythroid differentiation in some systems.
The degradation of the expressed silencing construct might lead to the formation of several different siRNA, which could repress expression of the target genes.
If this model is correct, one might also expect overexpression of ORCA2 to lead eventually to a decrease in expression of TDC and STR, as the ZCTs have been shown to repress expression of both these genes [ 19].
