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Therefore, the widespread restricted diffusion in sporadic CJD white matter in association with reactive astrocytic gliosis and microglial activation (although with rare prion deposition) might represent primary pathogenic events.
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The separation of bacteria into Group I and Group II is generally compatible with the topologies of phylogenetic trees of the conserved regions of DdRp subunits and concatenated ribosomal proteins and might represent the primary bifurcation in bacterial evolution.
Similar to other basic visual functions, it has been suggested that the counting process might represent a primary sensory function, perhaps based on cortical neurons specifically tuned to numerosity processing [9].
The authors speculated that these neutrophils might represent the primary source of 'arthritogenic' TNF-α in this situation.
Furthermore, metachronous lesions (which might represent independent primaries as we show in this case-series) are unlikely to be resected, mainly due to the local and/or distant diffusion of the disease, thus such relatedness is under-studied in the literature.
The available data represent primary tumors only.
It is important to point out that in primary melanoma where adequate surgical treatment has not been carried out, recurrence of melanoma in or adjacent to the scar might represent regrowth of residual primary disease rather than metastasis.
It was also reported that if all metastatic tumor sites were included in the analysis, then the HER-2/neu positive metastatic tumors with a corresponding negative primary tumor were more frequent than the converse, suggesting that HER-2/neu expression in primary tumors might represent an underestimation of reality.
The difficulty in classifying these tumors suggested that they might represent a transitional state between primary tumors and truly metastatic tumors.
Furthermore, as diabetes and cardiovascular disease share many common risk factors including HbA1c, combined diabetes and cardiovascular risk assessment in primary care might represent a more cost-effective approach to risk stratification [ 22].
A hypoxic profile that included 13 genes such as VEGF and ANGPTL4, has been associated with distant metastases and might represent an independent predictor of outcomes in primary breast cancers [27].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com