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Possibly, novel drugs targeting the glutamate glutamine cycle might represent new avenues towards a treatment of this deadly disease.
There could be similarly uncommon alterations that haven't yet been found and might represent new targets for drugs.
Recent investigations into the biology of minimal residual disease indicate that many early relapses derive from residual cells present at first diagnosis, but some late relapses might represent new mutations in leukaemic cells not eliminated by conventional therapy.
The differential gene expressions might represent new or additional endpoints useful for the mechanistic understanding and perhaps also the hazard assessment of the skin irritation potential of chemicals and products.
Cholecystokinin and related peptides are involved in the control of intestinal motility and cholecystokinin receptor ligands might represent new pharmacological tools for the treatment of symptoms associated with functional bowel disorders.
In this context, targeting SPHK1 or its downstream signaling molecules as identified by our present study might represent new and potential strategies against human glioma.
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The other two indigenous alphaproteobacterial phylotypes identified were only very distantly related to any described species or environmental sequences, and might thus represent new lineages of subsurface-associated microorganisms.
Long-term (13 20 years) clinical follow-up of randomized trials of BCS have revealed in breast recurrence rates ranging from 6 to 20 %, even when negative surgical margins were as wide as 1 2 cm; these and other studies have suggested that up to half of such local recurrences might actually represent new primary cancers arising in mammary tissue at risk for developing cancer [ 8].
This new ameba-resistant intracellular bacteria might represent a new etiologic agent of pneumonia because it is likely also resistant to human alveolar macrophages (2, 3 ).
The results indicate that these novel conjugates might represent a new class of anticancer agents.
"There's no rhyme or reason," she said, destroying my vision of an orderly universe in which higher model numbers might actually represent newer products.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com