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Recent work by Jeck et al. has also demonstrated that Alu motifs are preferably incorporated in noncoding RNA lariats, which might represent inactive isoforms and were also shown to exist for ANRIL [55,76].
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Unfortunately, the amount of the faster component labeled by the fluorescent agonist was too low for detailed analysis, although it was speculated that it might represent the inactive receptor (R) conformation, which normally has low affinity for agonists (14).
All were crystallised with inverse agonists or antagonists and therefore represent inactive conformations.
Serum starved cell extract represent inactive levels of rhoA while 0.2M GTP loaded extract represents fully active rhoA.
These structures were proposed to represent inactive (closed) and active (open) forms of the complex, respectively.
In this scenario, active individuals are perceived to represent inactive ones [ 18, 19].
Results are visualized in the same manner (thick edges represent active reactions and thin edges represent inactive reactions).
Therefore, it is possible that the 60S dimers induced by Sdo1p, if not an in vitro artifact, might represent a form of inactive storage of ribosomal subunits upon a certain stress (Fig. 6G).
We concluded that this unspecific band might represent a pseudogene, that is, an inactive copy of the cytochrome b gene inserted within nuclear or mitochondrial genomes.
Thus, the two different integrin β1 populations in the MUC1-negative cells released by NECDS might represent the open (active) and closed (inactive) integrin conformations of integrin β1 as a result of cell detachment and activation of integrin β1.
The apparent linear array of domains detected by small-angle x-ray scattering from a partially phosphorylated form of full-length Btk might represent the activated rather than the inactive form, in a conformation similar to that of activated c-Abl (Márquez et al., 2003; Nagar et al., 2006).
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