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Tryptanthrin, BII, and improved derivatives thereof have not been distributed on a commercial scale for application as antibacterial agents, and thus, they might represent attractive scaffolds for developing new antibacterials.

Indeed, both oncogenic and tumor suppressor roles have been proposed for a number of DUBs [18], [19], leading to the concept that they might represent attractive targets for novel cancer therapies ([20], [21] and references therein).

This suggests that the transfer of tumor-specific Th17 cells might represent attractive antitumor therapy.

That the proportion of FA that accumulate in TAG is very low (<0.8%) compared to total FA suggests that TAG assembly is limiting in duckweed tissue, and that increasing the expression of acyltransferases along with oil-body structural proteins such as oleosins and caleosins might represent attractive targets for increasing TAG accumulation [ 11, 35].

Because p38, ERK and JNK are each detected in their activated form in the synovial tissue of patients with various forms of inflammatory arthritis, and are requisite for pathology in animal models of arthritis, MAPKs might represent attractive therapeutic targets in the treatment of RA and other forms of arthritis.

Thus, despite the failure of recent clinical trials to demonstrate a beneficial effect for nimodipine in AD, there is substantial evidence that other DHPs might represent attractive candidate drugs that could be used to treat patients with mild-to-moderate dementia.

Similar(54)

Thus CysR might represent an attractive novel streptococcal drug target.

Therefore, Epac might represent an attractive therapeutic target in the treatment of prostate cancer.

Preliminary data indicate that mild hypothermia might represent an attractive approach to increase contractility not only after cardiac arrest but also in other patients with cardiogenic shock [ 48].

As these cellular functions are crucial for tumour growth and metastasis, Epac might represent an attractive therapeutic target in the treatment of prostate cancer.

Because TMCG/DIPY treatment positively influenced E2F1-mediated cell death [ 14], we hypothesised that this combination might represent an attractive strategy to target overexpressed E2F1 in 4OHT-treated ER-negative breast cancer cells.

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