Alternatively, genomes in one focus might replicate successively, before replication switched to another focus (model c).
This indicates that region-specific characteristics, such as an open chromatin structure, might facilitate replication initiation.
It suggests that SPAC27D7.08c might regulate replication by methylating downstream proteins.
We next sought to explore the molecular mechanism(s) by which Hdacs1,2 might promote replication fork progression.
The occurrence of BK polyomavirus might intensify replication of AdV, because the AdV load was significantly higher in co-infection than in samples with AdV infection alone.
The first peak might represent replication of the virus at the site of injection, perhaps in dendritic cells, which then migrate to the lymph nodes, causing the second burst of replication.
As one might expect, replication has been demonstrated to improve estimates of allele frequency, and therefore may be used to reduce, although by no means eliminate, the dilemma posed by false positive results [ 45].
It is possible that these sites of active, bidirectional strand invasion might represent replication origins (for example, at sites between repeats E-2 and O-2 and between repeats L-1 and G-2).
These results suggest that the Rif1-dependent recruitment of PP1 to replication origins might counteract DDK kinase activity at origins.
Rep gene sequences that are absent from tgAAC94 and whose presence might indicate replication-competent AAV were detected in the heart, trachea and right knee, but not in the blood, spleen, liver, brain or tonsils.
