Likewise, additional molecular switches have been observed already and might regulate redistribution of some metabolic functions throughout the hepatic lobule (e.g., gluconeogenesis, fatty acid oxidation, glutamine synthetase) or deal with the protein responsible for the maintenance of the hepatic zonation (e.g., β-catenin, E-/N-cadherins) upon liver injury and repair.
Alternatively, as Agrs belong to the superfamily of protein disulfide isomerases (PDI), which modulate folding of other proteins (Hatahet and Ruddock, 2009; Persson et al., 2005), they might regulate the folding of some extracellular proteins in the intercellular space.
Studies in mammalian cell lines have shown that the insulin receptor pathway can influence translation of HIF-1α, and recent studies in C. elegans have suggested that DAF-16 might regulate HIF-1 expression in some developmental or environmental contexts [28], [29].
This suggests that androgens might regulate, or be regulated by, some miRNAs.
In addition, given the various altered signalling cascades during oxidative stress, it is tempting to assume that some signals might regulate autophagy by interacting with the AMPK pathway.
This indicated that qGL3 might regulate grain length through regulation of the cell cycle.
They might regulate Cx43 expression by acting on some transcription factors which could target Cx43 gene promoter.
This leaves the assumption that GCE contains some unknown substance which might regulate the expression of HCD in L. johnsonii.
It appeared to us that some survivin family members might regulate autophagy.
Thus, independent mechanisms might regulate the cytoplasmic mislocalization of p27 in some tumors and its accelerated degradation in others.
