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The authors also identified transcription factors that might regulate responses to the pollutant exposures.
The advantage of ex vivo analysis is that it provides a platform to better understand the mechanisms that underlie tumour heterogeneity in the androgen metabolic pathway and identify other therapeutic targets that might regulate responses to pharmacologic therapy within the context of the native prostate architecture.
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(We continued to use either Cox-2 KO POBs or treat with NS398 because chronic exposure to PGE2 in the media might down regulate responses to added PGE2).
Although the role of SIRT1 in cancer is controversial, our results preliminarily demonstrated that SIRT1 might regulate adaptive responses to chemotherapy-induced stress and then facilitate chemoresistance.
To define the manner by which IFN-γ might regulate catabolic responses induced by IL-1β in humans we utilised an in vitro model system using the structural cells that constitute the inflammatory pannus, namely, FLS cultured from RA synovial tissue specimens.
Alternatively, presynaptic activity might regulate the response of axons to a repulsive signal in the cortex.
This association offers a potential mechanism by which chondrocytes might regulate their response to injury and thereby influence the progression of hip OA.
These consensus sites might regulate the response of TLR3 to RA since it has been shown that RA can control the expression and activity of transcription factors such as IRF1 and STAT1 in cancer cells.
To gain additional insight into adaptation of the mammary gland to altered milking frequency, we used evidence from the literature, as well as The Gene Ontology (http://www.geneontology.org), to determine functions associated with genes differentially expressed in response to IMF that might regulate milk yield responses.
The inhibition of respiration by neuron-specific cco-1 RNAi is sufficient to increase lifespan, and it induces the intestinal UTRmt response,104 suggesting that a systemic factor secreted from neurons might regulate global cellular responses.
To identify transcription factors that might regulate osmotic stress responses in vivo, we first performed an unbiased search of the promoters (1Kb) of all upregulated ORGs and their C. briggsae orthologs for transcription factor binding sites using all binding motifs described in the TRANSFAC motif database (www.gene-regulation.com; see 'Methods').
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