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Effects of various transcription factors on fast and slow promoters might reflect direct binding to gene regulatory sequences of such genes (regulation in cis as ultimate transcription factors), or they might regulate other genes that in turn regulate the genes determining fast and slow phenotype (Fig. 3).
This study also suggests that palmitoylation modifies proteins downstream of BMPR and upstream of p38 MAPK and this modification might regulate other cellular events that involve this pathway.
Overexpression of GIF1 and OsCIN1 also resulted in different phenotypes, suggesting that OsCIN1 might regulate other unrecognized biological process.
It also suggests that Pn might regulate other aspects of mitochondrial physiology besides stabilizing TFAM and promoting mtDNA replication.
This opens up the possibility that other microRNAs, which are also significantly induced by stimulation, might regulate other aspects of neuronal development and synapse formation.
Therefore, these TF might regulate other important genes for IMF FA composition not represented in this network and false positive results may be included in the network.
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Since KPNA5 has been reported to interact with ANP32A, an acidic phosphoprotein involved in proliferation, differentiation and apoptosis [35] and with p27Kip1, a cyclin-dependent kinase inhibitor involved in G1-phase arrest [36] we hypothesized that the KPNA5/BRMS1 complex might also regulate other cellular functions apart from nuclear import of BRMS1.
This result indicated that MYB4 might also regulate other important genes in the flavonoid biosynthetic pathway, in addition to C4H.
While TsES did not affect expression of TLR2 and TLR4 during sepsis, it might still regulate other TLR expressions and should be further investigated.
First, tDMRs present at the fetal stage might regulate processes other than differentiation.
These transcription factors (Table 1) were expressed in a time-dependent manner, suggesting that they might regulate each other.
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