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Persistence of Osborn waves was also reported by Vassallo and coworkers and might reflect underlying structural heart disease [ 14].
Accordingly, the 40% reduction of Apgar score in our study might reflect underlying mechanisms for HG rather than consequence of treatment.
We find it likely that these genes might reflect underlying growth programs that need to be coordinated with cell wall modifications.
It is possible that either low or high CD4 levels might reflect underlying immunologic mechanisms that could affect beta cell mass or function.
Furthermore, norms regarding gender roles and attitudes towards violence may be situational, so the observed differences might reflect underlying socioeconomic conditions that are not fully addressed in this paper.
For example, the ability to induce tumor regressions with tolerable doses of DNA-damaging cytotoxic agents might reflect underlying defects in DNA repair coupled with collateral pro-apoptotic signals delivered by oncoproteins such as E2F1 and c-Myc.
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This approach uses multivariate methods such as cluster analysis applied to a wide range of observed features including symptoms, signs or physiological measurements, in order to identify disease groups that might better reflect underlying biological pathways.
We hypothesised that this might, in part, reflect underlying physiological gradients and so we also investigated the cephalo-caudal stem-cell and Wnt signalling gradients in the GI tract of wild-type litter-mates.
However, gene expression profiling, by its nature, will not provide biochemical information on functional activities of proteins and might only in part reflect underlying genetic dysfunction.
Elevated pTH activity in ZI does not simply reflect underlying differences in enzyme expression and instead, might be due to neglectful mice having a heightened input to ZI.
While we believe that the trends suggested by our Asian-level GeoSSE analysis correctly reflect underlying processes, development of novel analytical frameworks might provide better ability to test these patterns at regional scales.
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