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These could be explained through systematic simulation experiments in terms of a combination of reduced total INa,T that might reflect reduced Na+ channel expression in combination with INa, Lassociated with Scn5a+/ΔKPQ.
All strains expressing Y. lipolytica Hsp70s were temperature sensitive at 37°C, which might reflect reduced ability of these Hsp70s to protect important cellular factors or possibly a lower thermal stability of Hsp70s that evolved with this organisms's lower optimal and maximal growth temperatures.
However, these reductions might reflect reduced assay sensitivity.
To some extent, these effects might reflect reduced activity of the Na+/K+-ATPase [ 23].
Consequently, observed differences in BOLD between children with and without DD might reflect reduced gray matter in corresponding regions.
Decreased MPO might reflect reduced circulating neutrophil numbers as a consequence of granulocyte migration to the site of inflammation, but this remains to be demonstrated.
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This might provide a potential link for the previously observed associations between apparent pathological conditions and low NAA and might also reflect reduced neuronal mass in these diseases.
Reduced thalamocortical volume might also reflect reduced cell and axon numbers in component structures.
As cell cycle progression depends on rapid protein turnover, this might also reflect reduced proteasome efficiency predicted by downregulation of proteasome subunits in the CNT/RNT.
However, to our knowledge no gene functions linking RFC1 directly with a mechanism which could be responsible for the trait variations are known and its low expression in resistant mice might simply reflect reduced requirement for DNA repair in more resistant animals.
The former association might be postulated to reflect reduced renal function, for AGEs that are not bound to long-living proteins, like collagen, may be retained and thus promote greater tissue damage, including greater binding to long-living proteins, and thus contributing to SIF.
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