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Data from population-based and clinic-based studies show that changes in retinal calibre are associated with systemic vascular risk factors and might reflect early microcirculatory alterations in people with diabetes prior to the onset of clinically significant complications, such as diabetic retinopathy.
As developed in Text S1, there is good reason to question if this unification might reflect early events in eukaryotic cell evolution, including the earliest adaptations of the eukaryotic cell to material properties of a soft inert microenvironment.
It thus may also be argued that the P1 in the present study might reflect early emotional processing of stimulus valence, since negative and positive emotions may be elicited when children see the feedback from having guessed a "bad" vs. a "good" prize, respectively.
Low exercise at baseline might reflect early cognitive impairment; this has been a criticism of papers that have evaluated exercise in relation to diagnostic states.[34] [36] In reply to such criticism, the relationship has been found to hold when other potential confounders – such as vascular risk or functional impairment – were included in the adjustment.
In two recent cohort studies, we suggested that UCEP might reflect early symptoms of gastrointestinal cancer [ 7], pancreatitis, and gallstone [ 8].
We included studies with any one of the following outcomes that might reflect early presentation: time from symptom discovery to presentation or diagnosis, stage of disease at diagnosis or survival/mortality.
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The incidence of fatal CMV pneumonia has decreased over the last 15 years, which might reflect earlier diagnosis or the use of pre-emptive therapy or more effective preventive strategies.
The response to availability of food during the SGP might reflect earlier selection, for instance, by a high mortality during the first year after birth.
While ovarian cancer is the leading cause of death in the UK from gynaecological malignancies, there have been improvements in survival in the past two decades, which might reflect earlier diagnosis and more effective treatments. 2 In general terms, the earlier the cancer is diagnosed, the more treatment options are available and the better the prognosis.
Hence, a crucial distinction between these ERP components would be that, whereas the ERN might reflect the early detection of a mismatch between motor representations remaining unavailable to conscious awareness, generation of the Pe depends, at least in part, on the conscious awareness of errors.
Decreased α-synuclein gene and protein expression in the Cln1/5 dko brain is a new finding that might reflect the early cortical neuron loss and needs further investigation.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com