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This autonomic imbalance might reflect alteration of central control mechanism [ 11, 12], and provide a target for pharmacotherapy [ 7, 13].
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To determine whether the reduced MHC class I expression might reflect alterations in the antigen processing and presentation in stem cells, we analyzed the expression of APM molecules by real-time PCR.
The observed decrease in metalloproteinases in the resistant strain might reflect an alteration in Bti Cry toxins activation in the gut lumen of LiTOX larvae.
34 In addition, PML is located on chromosome 15q, which is frequently lost in I-GIST, 17 suggesting that the decreased level of PML might reflect genomic alteration in I-GIST.
We therefore wished to examine the relationship between mammographic density, breast tissue composition and expression of stromal proteins, to establish whether the increased risk attributed to increased mammographic density might reflect stromal alteration.
Although neither study shows direct involvement of CLN3 in either BMP synthesis or palmitoyl-protein Δ-9 desaturation, respectively, these results might reflect downstream alterations in underlying membrane dynamics owing to the alterations in the phospholipids we report.
We therefore wished to examine the relationship between mammographic findings suggestive of malignancy in non-palpable breast carcinomas and the expression of stromal proteoglycans versican and decorin, to establish whether the increased risk attributed to these findings might reflect stromal alterations.
RT reduction and ISC increase reflect alteration of the epithelial permeability and enhancement of the ion flux which might be related to VCC-dependent channel formation.
It should also be noted that alterations in autonomic function might reflect a change in sympathetic or parasympathetic activity or in the balance of the two systems [ 53, 54].
IHC over-expression of p53 might reflect that genetic alterations also occurred in these tumors.
These last observations are consistent with the hypothesis that increased mammographic density might reflect primary stromal alterations, including SLRP expression, that could influence early tumorigenesis.
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