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Bisphosphonates might reduce bone graft resorption by inhibition of the osteoclasts [ 9].
In a recent comprehensive review [ 1], we suggest that tea and its bioactive components might reduce bone fracture risk by benefiting bone mineral density (BMD) and supporting osteoblastic activities while suppressing osteoclaistic activities, possibly due to their antioxidant and/or anti-inflammatory functions.
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The ability of MRK-003, a specific γ-secretase inhibitor (GSI), to delay the onset of bone metastasis suggests that blocking Notch activation in the bone marrow microenvironment might prevent or reduce bone metastasis in patients with breast cancer.
We also show that activating protein 1 (AP-1) family transcription factors could be one of the key regulators for the anabolic activity of subglutinol A. Such drugs with dose-dependent osteogenic activity might help reduce bone-associated side effects and be clinically useful for bone tissue transplantation.
The diuretics may reduce bone loss by reducing the amount of calcium excreted in the urine, the researchers theorize.
Oestrogens reduce bone resorption.
10 As for bone density, estrogens typically reduce bone resorption, thereby conserving bone mass.
Take biphosphates to reduce bone damage.
The ADAM9 gene is involved in the formation of multinuclear cells and, consequently, with osteoclast fusion [ 60]; its downregulation might result in reduced bone mass.
A reduction in the formation of free radicals and oxidative stress might reduce the rate of bone loss and muscle wasting in the elderly (4, 5).
Background: A reduction in the formation of free radicals and oxidative stress might reduce the rate of bone loss and muscle wasting.
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