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This finding may explain why two thirds of the strains in our study were not traditional virulence clones of ExPEC but clones whose ability to cause infection is limited to compromised hosts, in whom antibiotic resistance might provide selective advantage.
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Thus, W-Beijing strains could be more efficient in restoring fitness due to mutations in DNA repair enzymes, which might provide a selective advantage [8].
Therefore, the presence of some TLOα9 might provide a selective role in passaged strains.
Nevertheless, this might provide a selective explanation for why no retrovirus appears to have evolved biological vector transmission.
Limoli et al (2001) reported that the process of chromosomal breakage and recombination that accompanies CIN might provide some selective pressure for radioresistant variants.
In addition, these results suggest that the process of chromosome breakage and recombination that accompanies chromosome instability might provide some selective pressure for more radioresistant variants.
The enzyme IspE, catalyzing the intermediate step, is shown to mediate this interaction in E. coli [ 68], thus providing further support for the hypothesis that gene fusion might provide a selective advantage for substrate channeling in some species.
IS 6110 copy number is presumed to be under negative selection [ 67], however, in certain circumstances, it is the insertion site per se that might provide a selective advantage and not the copy number.
The latter might provide a selective advantage when one considers that about 50% of the N-glycosylation sites across all of its highly abundant VSG molecules are paucimannose or complex (Mehlert et al, 1998).
Clustering of virulence genes might provide a selective advantage, because all captured genes experience the same genomic environment, e.g. an open or closed chromatin structure, thereby being simultaneously amenable for transcriptional regulation [ 50].
They may represent traditional virulence clones of extraintestinal pathogenic E. coli (ExPEC) or low-virulence opportunists whose ability to cause disease is largely limited to compromised hosts, in which antimicrobial resistance might provide relevant selective advantage.
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