We next sought to identify which kinase targets might potentiate the effects of DDR1 inhibition.
70, 129, 130, 131 Other evidence suggests that inhibition of estrogen-related receptor alpha might potentiate the effects of fulvestrant.
Inflammatory cytokines induce apoptosis of corneal endothelial cells in an NO-dependent manner 22, and it is conceivable that arginase inhibition might potentiate this effect.
Findings from preclinical studies in animals have suggested that nicotine might potentiate the effect of antipsychotic agents used to treat TS.
There are also suggestions that the RAAS system is active in congenital heart disease, and that combinations of RAAS-inhibiting drugs that are used in the standard care for LV failure patients (such as angiotensin receptor blockers + eplerenone) might potentiate the effect and target oxidative stress, fibrosis and improve diastolic dysfunction like in the LV.
Here, we investigated whether addition of resveratrol would potentiate effects of rapamycin in mice.
Thereafter, developing inhibitors of the NF-κB pathway might potentiate the therapeutic effects of chemo drugs, through the mechanism of enhancing cell death [42].
History of AIDS-related pulmonary disease, and in particular recurrent pneumonia, was recently linked to an increase in lung cancer risk in the large HIV/AIDS Cancer Match study (Shebl et al, 2010), suggesting that HIV-related chronic inflammation might potentiate the carcinogenic effects of smoking in the lung (Engels et al, 2006).
The current investigation explored the interaction between ketamine and the opioid fentanyl in the anticipation that a low dose of ketamine might potentiate the analgesic effect of fentanyl.
To test the hypothesis that NO-Cbl might potentiate the anti-neoplastic effects of various chemotherapeutic agents, we measured antiproliferative effects in thirteen cell lines using 18 chemotherapeutic agents (Figure 1).
