Our work illustrated that members of the CYP1A family might play a complex role in hormonal regulation taking into account that CYP1A2 expression is mostly constitutive while that of CYP1A1 is highly inducible by a large range of xenobiotics, some of them being environmental pollutants and others being drugs [ 32].
These findings could highlight the notion that highly conserved genes within various species might play diverse and complex roles than previously recognized.
Together, these results show that even if CYP98A22 is phylogenetically related to CYP98A3, it might play a more complex or, at least, a different role in planta.
On the basis of the central role of the MRN complex in the maintenance of genomic integrity, germline heterozygous mutations affecting genes of the MRN complex might play a role in carcinogenesis.
These indicated that the chromatin remodeling complex might play important roles in cancer initiation and progression.
Kaiso's discovery as a nuclear DNA-associating protein and as a binding partner of the well described membrane protein p120ctn inspired researchers to speculate that a Kaiso-p120ctn complex might play an important role in cancer [18].
However, the expression of somite marker myod was increased in WTAP-, METTL3-, and double knockdown embryos, indicating that the WMM complex might play an inhibitory role in muscle development.
E. coli cells expressing the tccC1 homologue of X. nematophila became highly virulent towards G. mellonella, underlining the hypothesis that TccC1 toxin complex might play a major role in virulence [ 46].
Thus, in hair cells, the Cdh23, Harmonin, Myo7aa and Ift88 complex might play a structural role during biogenesis of the ERGIC by providing a physical platform for the required interaction between Trappc3 and Sec23 during homotypic fusion of COPII vesicles.
This Rnf complex might play a role in the supply with low-potential electrons for CO2 reduction to provide CO as a co-substrate in the initial carbonylation reaction.
