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Alternatively, inhibition of hypusine modification might perturb cellular carbon metabolism and thereby indirectly inhibit translation initiation (Castelli et al., 2011).
Increases in cellular cAMP levels might perturb cellular function via PKA or by Epac or CNG channels, other effectors of cAMP action.
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One possibility is that centrosome defects might also perturb cellular homeostasis: for example, stress pathways are often activated in response to centrosome defects in cultured cells, and stress contributes to tumourigenesis in some fly models.
New chemical methods that use small molecules to perturb cellular function in ways analogous to genetics have recently been developed.
When we perturb cellular physiology, metabolite homeostasis and intra‐ and intercellular partitioning can be affected in unpredictable ways.
Hypertonicity can perturb cellular functions, induce DNA damage-like responses and inhibit proliferation.
The mechanisms by which Hox proteins mediate their effects and how they perturb cellular functions are not well understood.
These findings suggest that the swd and trpm7 j124e1 mutations perturb cellular Mg2+ homeostasis, such that supplementary Mg2+ restores the cellular balance of Mg2+.
Lead (Pb) has been shown to perturb cellular calcium (Ca) homeostasis, altering sizes and flux rates of cellular pools of exchangeable Ca and impairing Ca-mediated cell processes.
As originally proposed by Khachaturian and colleagues (Khachaturian, 1987), the 'Ca2+ hypothesis of Alzheimer's disease (AD)' was based on observations that age-dependent increases in cellular Ca2+ are exacerbated in AD, which in turn might perturb multiple aspects of neuronal metabolism and activity (Peterson et al., 1985; Gibson and Peterson, 1987; Toescu et al., 2004).
High-throughput screening data from Toxicology in the 21st Century (Tox21) were also considered as a way to evaluate potential cellular pathways and generate -hypotheses for testing which and how certain chemicals might perturb biological processes related to diabetes and obesity.
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