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Although heterozygote advantage might operate during the brief gamete fertilization and diploid stages inside the mosquito host, balancing selection on proteins in the haploid asexual blood stage is probably due to negative frequency-dependent immune selection [12] [18].
The strong correlation we observed between MTCT of HIV-1 and DC-SIGNR genetic variants producing low levels of DC-SIGNR in the placenta suggested that mechanisms other than DC-SIGNR-mediated trans infection might operate during vertical transmission of HIV-1.
A similar mechanism might operate during the transcription of the CA9 gene.
This finding indicates that TLR modulation of cell responses to C5a is an extremely sensitive mechanism that might operate during the course of mild as well as severe infections.
Due to the distinct gender differences in smoking it might also be useful to make immigrant women and men aware of the social and cultural factors that might operate during the process of immigration and afterwards.
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All of these data suggest that selection for recognition between male and female gametes, modulation of nucleic acids, stress responses and signal transduction in the field during pollination might operate on these genes.
He anticipated that two or three extra trains would be introduced, but warned that they might only operate during peak times of the day.
Epigenetic mechanism might also operate during ET at the LAP promoter of the MEC, since mastitis induced expression of the LAP gene requires chromatin decompaction at the promoter [ 32].
But in practice they might operate a bit differently.
Intelligence agencies might operate on an even bigger scale.
How such effects might operate is unknown.
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