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Interestingly, a recent study suggested that utrophin upregulation in the brain might not rescue behavioral deficiency in mdx mice (Perronnet et al., 2012).
Because proteasome inhibitors restore retroviral reverse transcription without rescuing viral infectivity (Anderson et al, 2006; Wu et al, 2006; Kutluay et al, 2013), we reasoned that abrogating functionally important ubiquitination activities associated with TRIM5α should rescue reverse transcription, but might not rescue viral infectivity.
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Our results indicate that attenuation of mutants might be less pronounced in the embryo model compared to systemic murine infections and that complementation might not sufficiently rescue virulence phenotypes in all cases.
Therefore, the limited expression of Hsp90β in germ cells might explain why Hsp90β could not rescue germ cell development in Hsp90α KO testes.
Uncle Sam did not rescue our economy.
So why not rescue it?
He did not rescue himself.
The remaining proportion of multimapped reads not rescued might be due to genuine gene duplication events or mis-assembled segmental duplications [ 23].
It is the memory of waiting before he was rescued, and the persistent fear, rising up in his throat, that he might not have been rescued at all.
Thus, the deprived-eye arbors in the BoNT/E-treated cortex might not be completely rescued from retraction and become smaller than the normal arbors, although the extent of retraction is much smaller than that of the open-eye arbors in the inactivated cortex.
He isn't the type to dwell on how different things might have been if a pair of compassionate teachers had not rescued him.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com