Sentence examples for might not have functional from inspiring English sources

However, the juvenile endothelium has decreased responsiveness to NO (38 ) and increased levels of circulating asymmetric dimethylarginine, an inhibitor of NO synthase (39 ); thus, altered levels of NO might not have functional consequences in pediatric patients.

Sequence analysis of sarcoglycans indicated that although many missense mutations might not have functional consequences, they are intercepted by the quality control system, which significantly slows their processing and results in the disposal of the mutant protein.

Walking is difficult, and he does not have functional use of his right hand.

At the most trivial, false oestrus behaviour might not have any functional consequence but simply result from hormonal changes, perhaps as a result of pregnancy or through associating with females that are genuinely experiencing oestrus.

The lack of a C3 methyl group on ristosamine suggests that the producer might not have a functional EvaC homologue.

Clinical data suggest, although do not prove, that the R16H (found in normals as well), V49M (lack of LOH in tumor sample), and the A229V (also identified in unaffected subjects with compound heterozygosity for the pathogenic R304X mutation) changes might not have a functional impact, and this is supported by the weak or no effect on PDE4A5 binding.

Such sequences, although capable of becoming functional miRNA over long evolutionary time [ 14], might not have any immediate functional significance [ 15].

As to the high salt derived particles, it appears that they might not have a direct functional relevance to RbfA and RsgA, due to the high salt treatment.

The present data suggest that this mutation might not have the same functional consequences in rodents and marmoset monkeys as in humans.

Thus, important modifiers might not have been detected by our functional screen design.

Taken together, these data suggest that the culture conditions might not have been ideal to assess functional differences between cell fractions.