Because siblings grow up under the same roof, they are well versed in one another's quirks and foibles and consequently might not need as much breathing room as roommates who are not related.
In addition this connectivity leads to more robust systems that cannot be interfered by the inhibition of a single target of that network and consequently might not lead to the desired therapeutic effect [2].
Since the drugs might not affect JNK activation, consequently both drugs did not decrease the IL-6 production.
However, pravastatin, in contrast to other HMG coA reductase inhibitors, did not induce bone morphogenetic protein-2 formation in vitro[ 14], and consequently might not be expected to affect fracture risk.
In general, these stakeholders had a medicalised approach to IPV and consequently might not necessarily consider investing in actions aimed at prioritizing IPV and improving the response of health services.
One challenge in protein kinase affinity screening is that the most interesting selective inhibitors for protein kinases are expected to bind allosterically (at non-ATP binding sites) and consequently might not be detected.
Taken together, these data suggested that collagen IV was reduced in the extracellular space, leaving open the possibility that the RPE might not be polarised and consequently not functional, although there were indications that some kind of basal lamina was still present in Sec13-depleted eyes (see also Fig. 5D, inset).
Consequently they might not have provided sufficient scope for unanticipated topic areas to arise.
Further, there might be specifics of medical nutrition which might not allow easy modeling and consequently explain the limited uptake so far.
Alternatively, WRKY3 transcripts in the transgenic overexpression lines might not be full-length and, consequently, not functional for production of active WRKY3 proteins.
