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That is to say, these small synthetic peptides might not bind to hβ4-loop at a binding affinity similar to that of BKα subunit binding to hβ4-loop.
RelB/RelA interactions may not have been reported earlier because this complex might not bind well to typical κB DNA binding elements, or the level of this complex might be low compared to levels of other RelB complexes.
Intriguingly, G537 is the most commonly mutated residue in HIF-2α driven disease while the substitution of the non-polar, sulfur-containing Met residue with a polar Thr residue supports the notion that HIF-2α peptide might not bind pVHL with an identical motif as HIF-1α.
For example, their chemical specificity means that they might not bind to their targets in humans as they do in other species.The MHRA has decided that a working group of experts is now needed to decide how trials of this sort of drug can be handled more safely.
Further, even if the supertype relationship is known, peptides identified to bind to a representative HLA molecule within a supertype might not bind to one or several of the other members of the same supertype.
However, our data reveals that cucurbitacin B might not bind directly to tubulin or microtubules.
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This data suggested that APIP12 might not physically bind to Piz-t.
During the election campaign Trump suggested he might not be bound by this.
A new government might not feel bound to follow the same hard line as governments before.
Mr. Trump later suggested that he might not be bound by the One China policy, but he reaffirmed it during a call with Mr. Xi in February.
Mr Justice Ouseley said that the Supreme Court might not feel bound by a 1970 ruling that Scientology services "did not involve acts of worship".
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com