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As Met39 is located in a region that is not required for the CLV3 function [ 28], the cleavage might not be functionally relevant.
These truncated products might not be functionally active proteins.
This suggests that at least a fraction of these constrained elements might not be functionally important.
It is also possible that these differences might not be functionally relevant since p21CIP1 positive cells were more frequent and this may dominate the behavior of the population.
However, in the Vpu sequence from the subtype C of the group M HIV-1, the motif is replaced by the consensus sequence ExxxMV, which might or might not be functionally equivalent to the ExxxLV sequence.
Two additional missense mutations reside in apparently noncritical residues of the β-sarcoglycan cysteine-rich domain (N304S and D311N), which is a putative EGF-like sequence, and might not be functionally relevant, even though homozygous N304S causes a mild phenotype.
Similar(53)
Once these additional phosphorylation sites are validated independently, they may or may not be functionally relevant and might then be added to Reactome annotation.
Additionally, the dependence of facilitation and other ecosystem functions on coral cover could vary among subregions (e.g., 20% cover might not be universally functionally equivalent).
Altogether, the methylation and lower expression of GSDMB compared with ORMDL3 in peripheral blood leukocytes (Supplementary Material, Fig. S5) suggest that it might not be a functionally important asthma gene in the 17q21 locus.
Our study focuses on different components of fitness that might not be expected to be functionally related at least not via immediate and simple biochemical relationships.
Thus, many of these sites, which are likely to be functionally important, might not be detected using a naïve phylogenetic footprinting approach.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com